# Qunatification of Metabolites in MR Spectroscopic Imaging using Machine Learning

arXiv: https://arxiv.org/abs/1805.10201 · HTML: https://mlsanity.com/paper/1805.10201/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 25 May 2018.

## Built on by (most cited first, 1 of 1)

- [The Sim-to-Real Gap in MRS Quantification: A Systematic Deep Learning Validation for GABA](https://mlsanity.com/paper/2602.20289/) (2026)

## Abstract (arXiv)

Magnetic Resonance Spectroscopic Imaging (MRSI) is a clinical imaging modality for measuring tissue metabolite levels in-vivo. An accurate estimation of spectral parameters allows for better assessment of spectral quality and metabolite concentration levels. The current gold standard quantification method is the LCModel - a commercial fitting tool. However, this fails for spectra having poor signal-to-noise ratio (SNR) or a large number of artifacts. This paper introduces a framework based on random forest regression for accurate estimation of the output parameters of a model based analysis of MR spectroscopy data. The goal of our proposed framework is to learn the spectral features from a training set comprising of different variations of both simulated and in-vivo brain spectra and then use this learning for the subsequent metabolite quantification. Experiments involve training and testing on simulated and in-vivo human brain spectra. We estimate parameters such as concentration of metabolites and compare our results with that from the LCModel.