# Three-dimensional alteration of neurites in schizophrenia

arXiv: https://arxiv.org/abs/1804.00404 · HTML: https://mlsanity.com/paper/1804.00404/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 2 Apr 2018.

## Built on by (most cited first, 1 of 1)

- [Murine AI excels at cats and cheese: Structural differences between human and mouse neurons and their implementation in generative AIs](https://mlsanity.com/paper/2410.20735/) (2024)

## Abstract (arXiv)

This paper reports nano-CT analysis of brain tissues of schizophrenia and control cases. The analysis revealed that: (1) neuronal structures vary between individuals, (2) the mean curvature of distal neurites of the schizophrenia cases was 1.5 times higher than that of the controls, and (3) dendritic spines were categorized into two geometrically distinctive groups, though no structural differences were observed between the disease and control cases. The differences in the neurite curvature result in differences in the spatial trajectory and hence alter neuronal circuits. We suggest that the structural alteration of neurons in the schizophrenia cases should reflect psychiatric symptoms of schizophrenia.