# On the Safety of Machine Learning: Cyber-Physical Systems, Decision Sciences, and Data Products

arXiv: https://arxiv.org/abs/1610.01256 · HTML: https://mlsanity.com/paper/1610.01256/

## Key facts

- Cited by 52 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 5 Oct 2016.

## Built on by (most cited first, 30 of 52)

- [Uncertainty-aware Reward Model: Teaching Reward Models to Know What is Unknown](https://mlsanity.com/paper/2410.00847/) (2024)
- [Software Engineering for AI-Based Systems: A Survey](https://mlsanity.com/paper/2105.01984/) (2021)
- [Pitfalls of Epistemic Uncertainty Quantification through Loss Minimisation](https://mlsanity.com/paper/2203.06102/) (2022)
- [Socially Responsible AI Algorithms: Issues, Purposes, and Challenges](https://mlsanity.com/paper/2101.02032/) (2021)
- [Look Before You Leap: An Exploratory Study of Uncertainty Measurement for Large Language Models](https://mlsanity.com/paper/2307.10236/) (2023)
- [Is the Volume of a Credal Set a Good Measure for Epistemic Uncertainty?](https://mlsanity.com/paper/2306.09586/) (2023)
- [Second-Order Uncertainty Quantification: A Distance-Based Approach](https://mlsanity.com/paper/2312.00995/) (2023)
- [Robust Models are less Over-Confident](https://mlsanity.com/paper/2210.05938/) (2022)
- [ARM-Net: Adaptive Relation Modeling Network for Structured Data](https://mlsanity.com/paper/2107.01830/) (2021)
- [Label-wise Aleatoric and Epistemic Uncertainty Quantification](https://mlsanity.com/paper/2406.02354/) (2024)
- [Second-Order Uncertainty Quantification: Variance-Based Measures](https://mlsanity.com/paper/2401.00276/) (2023)
- [Towards Healthy AI: Large Language Models Need Therapists Too](https://mlsanity.com/paper/2304.00416/) (2023)
- [Explainability in Practice: A Survey of Explainable NLP Across Various Domains](https://mlsanity.com/paper/2502.00837/) (2025)
- [Evaluating Object (mis)Detection from a Safety and Reliability Perspective: Discussion and Measures](https://mlsanity.com/paper/2203.02205/) (2022)
- [Machine Learning with Requirements: a Manifesto](https://mlsanity.com/paper/2304.03674/) (2023)
- [Designing Fiduciary Artificial Intelligence](https://mlsanity.com/paper/2308.02435/) (2023)
- [Credal and Interval Deep Evidential Classifications](https://mlsanity.com/paper/2512.05526/) (2025)
- [Uncertainty in Contrastive Learning: On the Predictability of Downstream Performance](https://mlsanity.com/paper/2207.09336/) (2022)
- [On the Safety of Interpretable Machine Learning: A Maximum Deviation Approach](https://mlsanity.com/paper/2211.01498/) (2022)
- [Birds of a Feather Trust Together: Knowing When to Trust a Classifier via Adaptive Neighborhood Aggregation](https://mlsanity.com/paper/2211.16466/) (2022)
- [Uncertainty-aware predictive modeling for fair data-driven decisions](https://mlsanity.com/paper/2211.02730/) (2022)
- [Extending the Neural Additive Model for Survival Analysis with EHR Data](https://mlsanity.com/paper/2211.07814/) (2022)
- [Estimating and Controlling for Equalized Odds via Sensitive Attribute Predictors](https://mlsanity.com/paper/2207.12497/) (2022)
- [Uncertainty-Aware Boosted Ensembling in Multi-Modal Settings](https://mlsanity.com/paper/2104.10715/) (2021)
- [Know Your Model (KYM): Increasing Trust in AI and Machine Learning](https://mlsanity.com/paper/2106.11036/) (2021)
- [Dynamic Simplex: Balancing Safety and Performance in Autonomous Cyber Physical Systems](https://mlsanity.com/paper/2302.09750/) (2023)
- [DocXplain: A Novel Model-Agnostic Explainability Method for Document Image Classification](https://mlsanity.com/paper/2407.03830/) (2024)
- [Likelihood Annealing: Fast Calibrated Uncertainty for Regression](https://mlsanity.com/paper/2302.11012/) (2023)
- [Partial-Label Learning with a Reject Option](https://mlsanity.com/paper/2402.00592/) (2024)
- [Safety Monitoring of Machine Learning Perception Functions: a Survey](https://mlsanity.com/paper/2412.06869/) (2024)

## Abstract (arXiv)

Machine learning algorithms increasingly influence our decisions and interact with us in all parts of our daily lives. Therefore, just as we consider the safety of power plants, highways, and a variety of other engineered socio-technical systems, we must also take into account the safety of systems involving machine learning. Heretofore, the definition of safety has not been formalized in a machine learning context. In this paper, we do so by defining machine learning safety in terms of risk, epistemic uncertainty, and the harm incurred by unwanted outcomes. We then use this definition to examine safety in all sorts of applications in cyber-physical systems, decision sciences, and data products. We find that the foundational principle of modern statistical machine learning, empirical risk minimization, is not always a sufficient objective. Finally, we discuss how four different categories of strategies for achieving safety in engineering, including inherently safe design, safety reserves, safe fail, and procedural safeguards can be mapped to a machine learning context. We then discuss example techniques that can be adopted in each category, such as considering interpretability and causality of predictive models, objective functions beyond expected prediction accuracy, human involvement for labeling difficult or rare examples, and user experience design of software and open data.
