# Characterization of Lung Nodule Malignancy using Hybrid Shape and Appearance Features

arXiv: https://arxiv.org/abs/1609.06668 · HTML: https://mlsanity.com/paper/1609.06668/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 21 Sep 2016.

## Built on by (most cited first, 3 of 3)

- [Diagnose Like a Radiologist: Hybrid Neuro-Probabilistic Reasoning for Attribute-Based Medical Image Diagnosis](https://mlsanity.com/paper/2208.09282/) (2022)
- [CIRDataset: A large-scale Dataset for Clinically-Interpretable lung nodule Radiomics and malignancy prediction](https://mlsanity.com/paper/2206.14903/) (2022)
- [Machine Learning Applications in Lung Cancer Diagnosis, Treatment and Prognosis](https://mlsanity.com/paper/2203.02794/) (2022)

## Abstract (arXiv)

Computed tomography imaging is a standard modality for detecting and assessing lung cancer. In order to evaluate the malignancy of lung nodules, clinical practice often involves expert qualitative ratings on several criteria describing a nodule's appearance and shape. Translating these features for computer-aided diagnostics is challenging due to their subjective nature and the difficulties in gaining a complete description. In this paper, we propose a computerized approach to quantitatively evaluate both appearance distinctions and 3D surface variations. Nodule shape was modeled and parameterized using spherical harmonics, and appearance features were extracted using deep convolutional neural networks. Both sets of features were combined to estimate the nodule malignancy using a random forest classifier. The proposed algorithm was tested on the publicly available Lung Image Database Consortium dataset, achieving high accuracy. By providing lung nodule characterization, this method can provide a robust alternative reference opinion for lung cancer diagnosis.