# Identifiable Phenotyping using Constrained Non-Negative Matrix Factorization

arXiv: https://arxiv.org/abs/1608.00704 · HTML: https://mlsanity.com/paper/1608.00704/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 2 Aug 2016.

## Built on by (most cited first, 3 of 3)

- [Supervised multi-specialist topic model with applications on large-scale electronic health record data](https://mlsanity.com/paper/2105.01238/) (2021)
- [Unsupervised EHR-based Phenotyping via Matrix and Tensor Decompositions](https://mlsanity.com/paper/2209.00322/) (2022)
- [Towards a Fairer Non-negative Matrix Factorization](https://mlsanity.com/paper/2411.09847/) (2024)

## Abstract (arXiv)

This work proposes a new algorithm for automated and simultaneous phenotyping of multiple co-occurring medical conditions, also referred as comorbidities, using clinical notes from the electronic health records (EHRs). A basic latent factor estimation technique of non-negative matrix factorization (NMF) is augmented with domain specific constraints to obtain sparse latent factors that are anchored to a fixed set of chronic conditions. The proposed anchoring mechanism ensures a one-to-one identifiable and interpretable mapping between the latent factors and the target comorbidities. Qualitative assessment of the empirical results by clinical experts suggests that the proposed model learns clinically interpretable phenotypes while being predictive of 30 day mortality. The proposed method can be readily adapted to any non-negative EHR data across various healthcare institutions.