# Simultaneous whole-animal 3D-imaging of neuronal activity using light field microscopy

arXiv: https://arxiv.org/abs/1401.5333 · HTML: https://mlsanity.com/paper/1401.5333/

## Key facts

- Cited by 8 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 21 Jan 2014.

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- [Light-Field Microscopy for optical imaging of neuronal activity: when model-based methods meet data-driven approaches](https://mlsanity.com/paper/2110.13142/) (2021)
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- [Three-Step Conditional Diffusion 3D Reconstruction for Light-Field Microscopy](https://mlsanity.com/paper/2605.24959/) (2026)

## Abstract (arXiv)

3D functional imaging of neuronal activity in entire organisms at single cell level and physiologically relevant time scales faces major obstacles due to trade-offs between the size of the imaged volumes, and spatial and temporal resolution. Here, using light-field microscopy in combination with 3D deconvolution, we demonstrate intrinsically simultaneous volumetric functional imaging of neuronal population activity at single neuron resolution for an entire organism, the nematode Caenorhabditis elegans. The simplicity of our technique and possibility of the integration into epi-fluoresence microscopes makes it an attractive tool for high-speed volumetric calcium imaging.