# Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans

arXiv: https://arxiv.org/abs/1311.6406 · HTML: https://mlsanity.com/paper/1311.6406/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 25 Nov 2013.

## Built on by (most cited first, 1 of 1)

- [Fast deep learning correspondence for neuron tracking and identification in C.elegans using synthetic training](https://mlsanity.com/paper/2101.08211/) (2021)

## Abstract (arXiv)

A fundamental goal of systems neuroscience is to probe the dynamics of neural activity that drive behavior. Here we present an instrument to simultaneously manipulate neural activity via Channelrhodopsin, monitor neural response via GCaMP3, and observe behavior in freely moving C. elegans. We use the instrument to directly observe the relation between sensory stimuli, interneuron activity and locomotion in the mechanosensory circuit.